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Cami Renzoni is a creative writer and editor for The Recovery Village. As an advocate for behavioral health, Cami is certified in The information has been screened and edited by health professionals to contain objective information on diagnosis and treatment of diseases.


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Hydromorphone is an opioid medication used to treat moderate to severe pain. The extended-release form of this medicine is for around-the-clock treatment of moderate to severe pain, not for use on an as-needed basis for pain. What are the possible side effects of hydromorphone? Get emergency medical help if you have s of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitationhallucinationsfever, sweating, shivering, fast heart rate, muscle stiffness, twitchingloss of coordination, nausea, vomiting, or diarrhea. Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility ability to have children in men or women. It is not known whether opioid effects on fertility are permanent.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. What is the most important information I should know about hydromorphone? Keep the medication in a place where others cannot get to it.

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

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Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. What should I discuss with my healthcare provider before using hydromorphone? You should not take this medicine if you have ever had an allergic reaction to hydromorphone or other narcotic medicines, or if you have:.

Do not use hydromorphone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur.

MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. If you use opioid medicine while you are pregnant, your baby could become dependent on the drug.

This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks. Do not breast-feed. Hydromorphone can pass into breast milk and may cause drowsiness or breathing problems in a nursing baby. Follow the directions on your prescription label and read all medication guides.

Never use hydromorphone in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine. Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. Selling or giving away opioid medicine is against the law. Stop taking all other around-the-clock narcotic pain medications when you start taking hydromorphone. Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

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Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon. Do not stop using hydromorphone suddenlyor you could have unpleasant withdrawal symptoms.

Ask your doctor how to safely stop using hydromorphone. Never crush or break a hydromorphone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This can cause in death. Store at room temperature away from moisture, heat, and light.

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Throw away any unused liquid after 90 days. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription. Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

Since hydromorphone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time. Seek emergency medical attention or call the Poison Help line at A hydromorphone overdose can be fatal, especially in or other person using the medicine without a prescription.

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Overdose symptoms may include slow heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupilsvery slow breathing, or coma. What should I avoid while using hydromorphone? Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Opioid medication can interact with many other drugs and cause dangerous side effects or death.

Be sure your doctor knows if you also use:. This list is not complete.

Other drugs may affect hydromorphone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

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What happens if I overdose? Do not drink alcohol. Dangerous side effects or death could occur. What other drugs will affect hydromorphone? Be sure your doctor knows if you also use: other narcotic medications --opioid pain medicine or prescription cough medicine; a sedative like Valium -- diazepamalprazolamlorazepam, XanaxKlonopinVersed, and others; drugs that make you sleepy or slow your breathing --a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or drugs that affect serotonin levels in your body --a stimulant, or medicine for depression, Parkinson's diseasemigraine headaches, serious infections, or nausea and vomiting.

Where can I get more information? Your doctor or pharmacist can provide more information about hydromorphone.

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Remember, value this and all other medicines out of the reach of children, never share your medicines with others, and use this medication yellow for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be pill sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or street combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Life with Cancer.